Poly (ADP-ribose) polymerase 1 (PARP-1) is a critical enzyme involved in DNA damage repair and recombination, and shows great potential for drug development in the treatment of cancers with defective
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Inhibiting PARP-1/2 offered an important arsenal for cancer treatments via interfering with DNA repair of cancer cells. Novel PARP-1/2 inhibitors were designed by capitalizing on methyl- or ethyl-subs
Early and late apoptosis measured by annexin V and propidium iodide staining in human breast cancer cells revealed that the metastatic MDA-MB-231 cells pretreated for 24 h with artesunate, became resi
