Summary of clinical data and mTOR activity related p-4EBP1 in 49 primary ALL patients.

§cutoff equals 1.1 (OD p-4EBP1 ELISA).*based on cytogenetic and molecular genetic analysis; the hyperdiploid group also includes two cases with ETV6/RUNX1 fusion (good prognosis). High risk genetic lesions are: BCR/ABL fusion (two cases), ABL amplification (one case) and RUNX1 amplification (one case).#based on steroid response and current status; see methods: SR - standard, IR - intermediate, HR - high risk arm of the therapy; TX – transplantation, TRM - transplantation related mortality.φ– Fisher’s exact probability and,χ- chi2 tests.π- significant correlation with mTOR activity level.