A comparative epigenomics approach reveals REST as a mediator of Polycomb reprogramming during neuronal differentiation

ChEBI2012-09-04 更新2026-07-21 收录

神经元分化表观遗传调控

Polycomb重编程机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-27148 数据链接链接失效反馈

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A comparative epigenomics approach reveals REST as a mediator of Polycomb reprogramming during neuronal differentiation

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2012-09-04

REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells

Polycomb抑制复合物招募

神经元分化表观遗传调控

Polycomb Repressive Complex (PRC) 1 and PRC2 regulate genes involved in differentiation and development. However, the mechanism for how PRC1 and PRC2 are recruited to genes in mammalian cells is uncle

NIAID Data Ecosystem130

CRISPR and biochemical screens Identify MAZ as a co-factor in CTCF-mediated insulation at Hox Clusters [ChIP-seq_set3]. CRISPR and biochemical screens Identify MAZ as a co-factor in CTCF-mediated insulation at Hox Clusters [ChIP-seq_set3]

CTCF介导的染色质绝缘

神经元分化表观遗传调控

In this experiment, we sought to identify how the distribution of CTCF change in WT, MAZ HoxA(Δ5|6), MAZ HoxD(Δ4|8), and CTCF (Δ5|6:6|7) cells during differentiation of mouse embryonic stem cells (ESC

NIAID Data Ecosystem50

Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation. Mus musculus

染色质构象

神经元分化表观遗传调控

Mammalian chromosomes fold into arrays of megabase‐sized topologically associating domains (TADs), which are arranged into compartments spanning multiple megabases of genomic DNA. TADs have internal s

NIAID Data Ecosystem40

Transcriptional circuitry of NKX2-1 and SOX1 defines a previously unrecognized lineage subtype of small cell lung cancer to maintain neuroendocrine differentiation (Fixed-tissue ChiP-Seq Human). Transcriptional circuitry of NKX2-1 and SOX1 defines a previously unrecognized lineage subtype of small cell lung cancer to maintain neuroendocrine differentiation (Fixed-tissue ChiP-Seq Human)

非小细胞肺癌亚型

神经元分化表观遗传调控

Molecular classification of small cell lung cancer (SCLC), a lethal and heterogeneous disease, was recently proposed based on expression of four lineage-defining transcription factors SCLC-A (ASCL1),

NIAID Data Ecosystem50

The DNMT1 associated lncRNA Dali is an epigenetic regulator of neural differentiation [3]

神经元分化表观遗传调控

非编码RNA功能

Many intergenic long noncoding RNA (lncRNA) loci regulate the expression of adjacent protein coding genes. Less clear is whether intergenic lncRNAs commonly regulate transcription by modulating chroma

NIAID Data Ecosystem40

A comparative epigenomics approach reveals REST as a mediator of Polycomb reprogramming during neuronal differentiation

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