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IL-22+ T cells protect intestinal crypts from bacterial invasion and epithelial damage.

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114338
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Three subsets of intestinal epithelial cells (IECs) (P9, Surface; P10, Large Crypt; P11, Small Crypt) were isolated from Naïve and Day 9 C.r.-infected Cntrl (Cre-) and CD4 cre+. Il22 floxed mice (CD4 cKO) IECs from middle/distal colon regions (pooled from 2-4 mice per sample) were isolated with DTT, followed by EDTA, and then sorted into three populations (All were CD45-LD-EpCAM1+): CEACAM1Hi Surface, CEACAM1Int/lo SSCHi Large Crypt, and CEACAM1- FSClo SSClo Small Crypt cells
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2023-05-31
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