Occurrence of mutations1 and treatment outcome [25].

1WHO 2003 definitions: ACPR, LPF, LCF, ETF.2Blank cells indicate wild �Ctype sequence at the indicated codon; + indicate a mutation at the codon present in malaria isolates that were sensitive to SP; ++ indicate mutation present in malaria isolates that were resistant to SP.3Bolivian Repeat insert.4Genotypes: (1) DHFR 108/51/64 (with BR); (2) DHPS 581/437/540;