BIOGRID CURATED DATA FOR MRCK-1 (Caenorhabditis elegans)

Protein-Protein, Genetic, and Chemical Interactions for MRCK-1 (Caenorhabditis elegans) curated by BioGRID (https://thebiogrid.org); DEFINITION: mrck-1 encodes a serine/threonine-protein kinase that is orthologous to human MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) and DMPK (dystrophia myotonica-protein kinase, OMIM:605377); during development, MRCK-1 functions together with LET-502/ROCK to effect embryonic elongation through regulation of the MLC-4/myosin regulatory light chain; an MRCK-1::GFP fusion protein is expressed during embryogenesis in the lateral hypodermal seam cells, as well as in the dorsal and ventral hypodermis, the pharynx, and the dorsal and ventral nerve cords; in the hypodermal cells, MRCK-1::GFP forms parallel bundles, consistent with co-localization with filamentous actin and the non-muscle myosin II complex.

蛋白质-蛋白质、遗传以及化学相互作用数据集，针对线虫MRCK-1（秀丽隐杆线虫）由BioGRID（https://thebiogrid.org）编纂；定义：mrck-1编码一种丝氨酸/苏氨酸蛋白激酶，该激酶与人类MRCK（肌强直性营养不良激酶相关Cdc42结合激酶）以及DMPK（肌强直性营养不良蛋白激酶，OMIM:605377）同源；在发育过程中，MRCK-1与LET-502/ROCK协同作用，通过调节MLC-4/肌球蛋白调节轻链以实现胚胎伸长；在胚胎发生期间，MRCK-1::GFP融合蛋白在侧腹下表皮缝细胞、背腹下表皮、咽部以及背腹神经索中表达；在表皮细胞中，MRCK-1::GFP形成平行束，与丝状肌动蛋白和非肌肉肌球蛋白II复合物的共定位一致。