Field Effects in Gastric Cancer

Field effect in cancer, also called “field cancerization”, attempt to explain the development of multiple primary tumors and locally recurrent cancer. The concept of field effect in cancer has been reinforced, since molecular alterations were found in tumor-adjacent tissues with normal histopathological appearances. With the aiming of investigating field effects in Gastric Cancer (GC), we conduced a high-throughout sequencing of the miRnome of four GC sample and their respectively tumor-adjacent tissues and compared them with the miRnome of a gastric antrum sample from patients without GC, assuming that tumor-adjacent tissues could not be considered as normal tissue.