Effects of PCB 52 Exposure Via Sub-Acute Nose-Only Inhalation on Gene Expression in Livers of Adolescent Rats

Polychlorinated biphenyls (PCBs) are persistent environmental toxicants that pose a variety of health risks in humans. PCB 52 has been found in the indoor air of schools where adolescent students and staff are being actively exposed. This study examined the livers of adolescent Sprague-Dawley rats after sub-acute exposure to PCB 52 via nose-only inhalation. Rats were exposed for 4 hours daily for 28 consecutive days. RNA extracted from both male and female livers were submitted for RNA sequencing to compare the effects of PCB 52 on the expression of genes in the liver. Overall design: To determine the gene expression alterations following PCB 52 inhalation exposure in adolescent rats, male and female livers were processed for RNA sequencing. (N = 6 per sex)