Association between histopathological grading, immunohistochemical markers and prognosis in canine cutaneous mast cell tumor

The aim of this study was to evaluate the association between biologic behavior and survival time of dogs with cutaneous MCT with prognostic indicators. This prospective and longitudinal study followed 37 dogs with MCT. We correlated clinical factors (age, gender, time of onset, number of lesions, ulceration, tumor size, lymph node and distant metastasis, and recurrence rate) with histologic grading, immunohistochemical staining for Ki67 (samples were classified as &gt;23 positive cells/5 HPF or ≤23 cells/5 HPF) and KIT pattern (cytoplasmic or membranous). <br>