Expression of cell-surface and soluble proteins in study participants with VAP, non-VAP and NVC.

The median and interquartile range for each patient group is reported. Statistically significant differences between groups were determined using the Mann-Whitney U and post hoc Dunn correction as follows: VAP and non-VAP versus NVC (p*, VAP versus NVC (p† and non-VAP versus NVC (p‡, VAP versus non-VAP and NVC (p§, VAP versus non-VAP (p**, VAP versus non-VAP (p††, VAP versus NVC (p‡‡, VAP versus non-VAP (p§§ and NVC>non-VAP (pll. The lower limits of detection for the sTREM-1, IL-1β, IL-6, IL-8 and PCT assays were 0.01 µg/ml, 0.001 µg/ml, 0.0007 µg/ml, 0.004 µg/ml and 0.05 ng/ml respectively. N/A indicates below assay detection limit. BALF levels were corrected for dilution occurring with bronchoscopy using urea analysis. BALF/blood ratios were only calculable if BALF and blood measurements were obtained. VAP = ventilator-associated pneumonia. Non-VAP = ventilated patients with no evidence of pulmonary infection. NVC = non-ventilated non-infected patients.Expression of cell-surface and soluble proteins in study participants with VAP, non-VAP and NVC.