Model destription: The model describes the dynamics of murine IRF7 gene expression upon IFN stimulation. The present model comprises known key components and feedback mechanisms. The overall system
Probabilities were calculated using a Monte Carlo algorithm with 1000 runs in GINsim. E1 represents GoF and KO represents LoF of the corresponding element of the circuit.
(A) Values used for the PU.1–GATA-1 network in Equation 3. (B) Values of the additional parameters used for the PU.1–GATA-1 network including the gene X in Equation 4. For Figure 2A, , and for Figure
