Top gene sets enriched for hypermethylated genes.

Gene set enrichment analysis of genes near DMRs that are hypermethylated in severe SS cases relative to mild SS cases. Candidate gene sets include GO gene sets from the Molecular Signatures Database (30), genes known to harbor differentially-methylated CpG sites between SS cases and non-cases (SS DMP genes) (9), and genes known to be differentially expressed between SS cases and healthy controls (SS DE genes) (57). n = number of overlapping genes; adj. p-value = Benjamini-Hochberg adjusted p-value. (XLSX)