Striatal Cholinergic Transmission in an Inducible Transgenic Mouse Model of Paroxysmal Non-Kinesiogenic Dyskinesia

BEHAVIOR: Prism GraphPad file with AIMs and dystonia scores for all animals included in the study and exposed to vehicle, caffeine or quinpirole.

EPHYS: Excel files contain 2-min-binned firing rates values for each recorded cholinergic interneuron before and after application of quinpirole or caffeine. Excel file "WTvsPNKD ChI firing baseline" contains firing rates only at baseline of all interneurons from different experiments, used to perform a nested analysis. Prism GraphPad files show the statistical analyses performed on firing rate data.

FIBER PHOTOMETRY: Raw in vivo fiber photometry recordings (alldata[...].csv) acquired with Neurophotometric FP3002 system version 0.5.6 and Bonsai software + video recordings (video.avi) of freely moving mice during photometry acquisition. KeyDown files contain the timestamp of caffeine/quinpirole/vehicle injections. Video.csv files align video frames to photometry data. The analysis folder contains all the Matlab scripts used to analyze the data as described in "steps to reproduce".

MICRODIALYSIS: Prism GraphPad file with values of ACh concentrations obtained from HPLC analysis of microdialysate samples obtained from all the animals included in the study.