Data for: Comparison of parameters affecting GNP-loaded choroidal melanoma dosimetry; Monte Carlo study

The results of our study indicate the significance of using a full Monte Carlo model of human eye
globe instead of water phantom for the sake of precise ophthalmic dosimetry in the presence of
GNPs. The significance of GNPs’ size effect on macroscopic dose enhancement in choroidal
melanoma was also demonstrated, with implications on larger diameter GNPs in combination with
a high concentration depositing more energy on a macroscopic level. This study also specifies the
efficacy of low energy photon sources in the presence of GNPs in yielding a high dose to the region
of interest.
Experimental works on a wide range of sizes and concentrations of GNPs is a prerequisite in the
precise brachytherapy treatment of choroidal melanoma which will be conducted in future studies.

本研究的结果表明，在存在金纳米颗粒（GNPs）的情况下，为了精确的眼科剂量学，使用完整蒙特卡洛模型模拟人眼眼球而非水等效物的重要性。本研究亦揭示了GNPs尺寸效应对脉络膜黑色素瘤宏观剂量增强的影响，尤其是较大直径的GNPs与高浓度沉积相结合时，在宏观层面会积累更多的能量。此外，本研究还阐明了低能量光子在GNPs存在下，对目标区域实现高剂量输运的有效性。在未来的研究中，对GNPs的多种尺寸和浓度进行实验性研究，是精确近距离放射治疗脉络膜黑色素瘤的先决条件。