CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid

CEBPE is expressed exclusively in myeloid progenitor cells and is required for terminal differentiation of granulocyte precursors. Transcription of CEBPE is activated by at least 3 mechanisms: <br>1) CEBPA dimers bound to the promoter of CEBPE (Yamanaka et al. 1997, Matusushita et al. 2008, Loke et al. 2018, and inferred from mouse homologs), <br>2) SPI1 (PU.1), PML. and EP300 bound to the promoter of CEBPE (Yoshida et al. 2007), and <br>3) retinoic acid activation of the RARA:RXR retinoic acid receptor bound to the CEBPE promoter (Park et al. 1999, Verbeek et al. 1999, Cai et al. 2010, Iriyama et al. 2014). Activation of CEBPE by retinoic acid is believed to ameliorate some cases of leukemia (Park et al. 1999).

CEBPE（细胞因子增强子结合蛋白E）仅在髓系祖细胞中表达，并对于粒系祖细胞的终末分化至关重要。CEBPE的转录激活至少通过以下三种机制实现：
1) CEBPA二聚体与CEBPE启动子结合（Yamanaka等，1997；Matusushita等，2008；Loke等，2018；并从小鼠同源基因中推断），
2) SPI1（PU.1）、PML和EP300与CEBPE启动子结合（Yoshida等，2007），以及
3) 维甲酸通过激活RARA:RXR维甲酸受体与CEBPE启动子结合（Park等，1999；Verbeek等，1999；Cai等，2010；Iriyama等，2014）。据信，维甲酸通过激活CEBPE可以改善某些类型的白血病（Park等，1999）。