Rhodium(I)-Catalyzed Asymmetric Carbene Insertion into B–H Bonds: Highly Enantioselective Access to Functionalized Organoboranes

A unique
rhodium­(I)-catalyzed asymmetric B–H insertion of α-diazo
carbonyl compounds with easily available amine–borane adducts
was achieved using a newly developed C1-symmetric chiral diene as ligand. This first Rh­(I)–carbene-directed
B–H insertion example represents an attractive and promising
approach for synthesis of highly enantio­enriched organoboron
compounds, allowing for the efficient construction of α-boryl
esters and ketones with excellent enantio­selectivities (up to
99% ee) under exceptionally mild conditions.