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Proteomic Signatures of Dental Enamel

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Exposure to excessive fluoride can lead to dental enamel hypomineralization characterized by retention of enamel matrix proteins(EMPs). However, the types and functions of EMPs from different fluoride exposure pathways remains elusive. This study selected moderate-to-severe coal-fired dental fluorosis enamel(CDF), water-drinking dental fluorosis enamel(WDF) and healthy permanent dental enamel (H) from the residents (local until age 12). EMPs were extracted, digested, and analyzed via nanoLC-HRMS/MS, followed by database searching and bioinformatics.

创建时间:
2025-10-01
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