Mutagenesis by fragile Alu-IRs depends on the distance of reporter from the DSB site.

aTP denotes telomere-proximal location of URA3 with respect to the Alu-IRs.bTD denotes telomere-distal location of URA3 with respect to the Alu-IRs.cNumbers in parentheses indicate 95% confidence intervals.*Depicts mutation rates significantly higher than the wild-type strain at the respective loci (P#Depicts mutation rates in Δrev3 and Δsae2 strains significantly lower than the pol3-P664L strain at the respective loci (PND - not determined.