Additional file 1 of Novel pathological predictive factors for extranodal extension in oral squamous cell carcinoma: a retrospective cohort study based on tumor budding, desmoplastic reaction, tumor-infiltrating lymphocytes, and depth of invasion

Additional file 1: Clinicopathological status of 186 surgically resected specimens. Supplementary Table 1. The clinicopathological features were evaluated as follows; Sex (0: female; 1: male); cDOI 5 mm (0: ≤5 mm; 1: <5 mm); cDOI 10 mm (0: ≤10 mm; 1: DOI >10 mm); pDOI 5 mm (0: ≤5 mm; 1: <5 mm); pDOI 10 mm (0: ≤10 mm; 1: DOI >10 mm); Metastasis (0: absence; 1: presence); Number of lymph node metastases (0: n=0; 1: n=1; 2: n≥2); Pattern of invasion (1: pattern of 1 and 2; 2: pattern of 3 and 4); LyV (0: absence; 1: presence); pT (0: pT1, 2; 1: pT3, 4); pN (0: no LN metastasis; 1: pN1; 2: pN2 and 3); ENE (0: absence; 1: presence); DR (0: DR-M; 1: DR-I); TB (0: TB-L; 1: TB-H); TILs (0: TILs-L; 1: TILs-H); TB-H/pDOI>10 mm (0: no; 1: yes); DR-I/TILs-L (0: no; 1: yes); DR-I/TILs-L/pDOI >10 mm (0: no; 1: yes). MRI and CT were used in measuring the cDOI. Each unknown mass and artifact indicates that MRI could not detect a mass due to the small size, superficial location, or artifact. cDOI, clinical depth of invasion; pDOI, pathological depth of invasion; pT, pathological T; pN, pathological N; ENE, extranodal extension; LyV, lymphovascular invasion; DR, desmoplastic reaction; TB, tumor budding; TILs, tumor-infiltrating lymphocytes; TB-H, high tumor budding; DR-I, immature desmoplastic reaction; TILs-L, low-grade tumor-infiltrating lymphocytes; MRI, magnetic resonance imaging; CT, computed tomography.