Data and code for the integrative transcriptomic analysis of CdCl2-induced renal tubular injury and clear cell renal cell carcinoma

This dataset contains processed data, supporting tables, and R scripts associated with the study “Integrative transcriptomic analysis identifies shared stress-response and epithelial identity programs between CdCl2-induced renal tubular injury and clear cell renal cell carcinoma.” The study integrates the GSE27094 transcriptomic dataset of cadmium chloride-exposed HK-2 renal tubular cells with TCGA-KIRC RNA-seq and clinical data. The deposited materials include the final Supplementary Tables S1–S14, selected processed matrices, numerical data underlying the revised paired tumor-normal and multivariable survival analyses, and scripts for data acquisition, validation, differential expression, gene-signature integration, Gene Ontology enrichment, STRING protein-protein interaction analysis, paired TCGA-KIRC sensitivity analysis, survival modeling, and figure generation. Primary data are publicly available from the Gene Expression Omnibus under accession GSE27094 and from the NCI Genomic Data Commons under project TCGA-KIRC. Independent external validation results from GSE53757 and GSE40435 are summarized in Supplementary Table S12. No directly identifying participant information is included. The results are hypothesis-generating and do not establish a causal relationship between cadmium exposure and clear cell renal cell carcinoma.