Next Generation Sequencing of LdlrKO LXRα-phosphorylation disrupted macrophage transcriptomes
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE112213
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资源简介：
Liver X Receptors (LXRα and β) are ligand-activated transcription factors that play a key role in the control of lipid homeostasis, as well as modulation of immunity and inflammation. Besides ligand binding, LXR activity can be regulated by posttranslational modifications, such as phosphorylation. This study aims to assess changes in bone marrow derived macrophage transcriptional profiles of mice that carry LysMcre directed phosphorylation deficient-version of LXRα compared (S196A) to wild-type (WT). BMDM mRNA profiles of either LdlrKO or M-LXRα-S196A-LdlrKO male mice after being fed a Western diet for 12 weeks. 12 samples, 4 groups, in triplicate: (1) LdlrKO basal, (2) LdlrKO+ ligand, (3) M-LXRα-S196A-LdlrKO basal, (4) M-LXRα-S196A-LdlrKO+ligand
创建时间：
2019-03-25
