Major changes in ClinicalTrials.gov registry fields for 8 WHO Minimum Data Set items in 31 RCTs out of 123 RCTs with one or more changes in the registry after the initial registration.*

*Major modification of the registered data was defined as either a qualitative change – difference in the meaning of the information provided in the registry field, or a quantitative change – difference in the numerical entry in the registry field. For 1 out of 9 evaluated items (Item 12 ‘Health Condition(s) or Problem(s) Studied’), we did not record any changes.