1000IBD

The department of Gastroenterology and Hepatology of the University Medical Center Groningen initiated the 1000IBD project to prospectively follow more than a 1000 IBD patients from the Northern provinces of the Netherlands. We have collected a uniquely large number of phenotypes and generated multi-omics profiles for these patients. To date, 1,215 participants have been enrolled in the 1000IBD project, and enrolment is on-going. Patients that participate in the 1000IBD project are followed prospectively and the phenotype data includes information on dietary and environmental factors, and drug response. Genome information has been generated using genotyping (ImmunoChip, Global Screening Array, and HumanExomeChip), and sequencing (whole exome sequencing, and targeted resequencing of IBD susceptibility loci), transcriptome information generated using RNA-sequencing of intestinal biopsies, and microbiome information generated using both sequencing of the 16S rRNA gene and whole genome shotgun metagenomic sequencing.格罗宁根大学医学中心（University Medical Center Groningen）胃肠病与肝病学部门启动了1000IBD项目，旨在对荷兰北部省份的千余名炎症性肠病（Inflammatory Bowel Disease, IBD）患者开展前瞻性随访。本项目已为受试者采集了规模独特的多维度表型数据，并生成了多组学图谱。截至目前，1000IBD项目已累计纳入1215名参与者，且招募工作仍在持续进行。参与本项目的患者将接受全程前瞻性随访，其表型数据涵盖饮食与环境因素、药物反应等相关信息。基因组信息的获取采用了两类技术：一是基因分型，包括免疫芯片（ImmunoChip）、全基因组筛查阵列（Global Screening Array）及人类外显子组芯片（HumanExomeChip）；二是测序，包括全外显子组测序、炎症性肠病易感基因位点靶向重测序。转录组数据来源于肠道活检组织的RNA测序；微生物组数据则同时通过16S rRNA基因测序与全基因组霰弹枪宏基因组测序两种方法生成。

搜集汇总

背景与挑战

背景概述

1000IBD（Parelsnoer IBD）是荷兰的一个前瞻性全国性生物库和队列研究，专注于炎症性肠病（IBD）患者，包含1200名成年参与者。该数据集旨在通过多组学数据（如基因组学、蛋白质组学）和丰富的临床信息（包括生物样本、生活方式和医疗记录），促进IBD的病因、病程和治疗反应的转化研究，支持个性化医疗。