TP53 stimulates BNIP3L expression
收藏reactome.org2025-01-16 收录
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TP53 (p53) and CREBBP (CBP) bound to the BNIP3L gene stimulate expression of the BNIP3L. BNIP3L is an outer mitochondrial membrane protein that belongs to the BCL2 family and promotes apoptosis of cells under hypoxic stress (Fei et al. 2004).
TP53(p53)与CREBBP(CBP)结合于BNIP3L基因,可激活BNIP3L的表达。BNIP3L是一种定位于线粒体外膜上的蛋白质,隶属于BCL2家族,并在缺氧应激条件下促进细胞凋亡(Fei et al. 2004)。
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