Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 D311N in Complex with CCG273441

Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 D311N in Complex with CCG273441 Descriptor: (3Z)-3-{[4-(2-chloroacetamido)-3,5-dimethyl-1H-pyrrol-2-yl]methylidene}-N-[(1R)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide, G protein-coupled receptor kinase 5 Authors: Chen, Y, Tesmer, J.J.G. Deposit date: 2023-09-21 Release date: 2023-12-13 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes. Eur.J.Med.Chem., 264, 2023