The effects of CD4 T cell Nr4a family on NASH progression

NASH is characterized by hepatic steatosis, inflammation, fibrosis and liver damage, which eventually results in liver dysfunction due to cirrhosis or hepatocellular carcinoma. However, the cellular and molecular mechanisms underlying NASH progression remain largely unknown. In this study, we aimed to elucidate the impact of Nr4a family in CD4 T cells in NASH development. Hepatic CD4 T cells from WT or T cell specifc Nr4a1/2 deficient mice fed a choline deficient, high-fat diet consisting of 60 kcal% fat and 0.1% methionine diet were sorted. We performed gene expression profiling analysis using data obtained from the pooled cells (n=2 per group).