Summary of the genetic association and interaction results using PLINK.

BSI: Brief Symptom Inventory; BSI-DEP: BSI depression score; BSI-ANX: BSI anxiety score; CHA: childhood adversity; DEP: lifetime depression; Pperm: permutated p values; RLE: recent negative life events (in the last year). Additive genetic models were calculated, where 5-HTTLPR s allele represents the minor allele. Results are displayed in different groups: total population (all); those up to 30 years (≤30); and those above 30 years (>30). Regression equations (linear regression and beta for BSI-DEP and BSI-ANX scores, and logistic regression and odds ratio for DEP) always involve gender and age as covariates. In case of interaction models, main effect of the respective life event (RLE or CHA) was also covariate in the equation, besides its interaction with 5-HTTLPR. And in case of the third model BSA-ANX was also a covariate. Permutated p values were calculated for the nominal p<0.05 results using PLINK—mperm 1000 for main 5HTTLPR effect on anxiety and using the “glmperm” R-package (http://cran.r-project.org/web/packages/glmperm/index.html, with 1000 permutations) for the interaction effects on DEP and BSI-DEP.
The three categories of RLE were: low = 0–1, medium = 2, high = 3 or more number of recent negative life events. The three categories of CHA were: low = 0–3, medium = 4–6, high = 7 or more scores.
Italics represent trends, and bold represents significant findings.
Summary of the genetic association and interaction results using PLINK.