Data_Sheet_1_Case Report: Triple Primary Malignant Tumors of the Esophagus, Stomach, and Colon in a Patient With Genetic Analysis.PDF

The incidence of multiple primary malignant tumors (MPMTs) has increased greatly with the progress of tumor diagnosis and therapy technology. However, triple primary cancer is still very rare, and its genetic change is not clear yet. This case report described a 70-year-old Chinese male patient with triple primary cancers of the esophagus, stomach and right-sided colon. Pathological examination confirmed that each malignant tumor developed independently. Next-generation sequencing (NGS) using a 599-gene panel revealed five TP53 mutations in three tumor tissues. These variations might contribute to development of the triple primary malignant tumors in the patient. The patient underwent laparoscopic feeding jejunostomy and postoperative radiotherapy for synchronous esophageal and gastric carcinomas. Then, he underwent laparoscopic-assisted resection of right-sided colonic cancer and lysis of abdominal adhesions. By the time of submitting this manuscript, the patient had been well and no sign of recurrence or metastasis had been observed. To the best of our knowledge, this case is the first one to clarify the genetic abnormalities of triple primary cancers of esophagus, stomach and colon in a Chinese patient. It may contribute to understanding the molecular pathogenesis of multiple primary digestive malignancies and providing valuable treatment strategies for the similar patients in the future.

随着肿瘤诊断与治疗技术的进步，多原发恶性肿瘤（MPMTs）的发病率显著上升。然而，三原发癌症仍然十分罕见，其遗传学改变尚不明确。本病例报告描述了一位70岁的中国男性患者，其患有食管、胃及右侧结肠的三原发癌症。病理学检查证实每个恶性肿瘤均独立发展。采用599基因面板进行下一代测序（NGS）检测，在三处肿瘤组织中发现了五个TP53突变。这些变异可能促进了患者三原发恶性肿瘤的发生。患者接受了腹腔镜喂养空肠造口术及术后针对食管和胃癌的放疗。随后，他接受了腹腔镜辅助右侧结肠癌切除术及腹腔粘连松解术。截至提交本论文之时，患者状况良好，未观察到复发或转移的迹象。据我们所知，此病例是首次阐明中国患者食管、胃及结肠三原发癌症的遗传异常。这或许有助于理解多原发消化系统恶性肿瘤的分子发病机制，并为未来类似患者的治疗策略提供宝贵的参考。