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Targeting Germline and Tumor Associated Nucleotide Excision Repair Defects in Cancer
Genetic alterations in members of the nucleotide excision repair (NER) pathway are present in a wide spectrum of cancers, but specific treatment options for this patient population are scarce. Here, w
干细胞与再生医学数据中心2022-02-20 更新90
Expression profile of HNF1A knockdown and overexpression in 22RV1 and LNCaP cells respectively
To determine genes regulated by HNF1A in 22Rv1, we performed siRNA mediated knockdown of HNF1A using pooled siHNF1A (L-008215-00-0005 5 nmol) and pooled siSCR purchased from Dharmacon. RNA was harve
干细胞与再生医学数据中心2022-02-20 更新40
Identification of RUNX1 targets in iLSCs
We identified 2 phenotypically and functionally distinct populations in our AML-iPSC line upon hematopoietic differentiation. One population is phenotypically and functionally a leukemia stem cell pop
干细胞与再生医学数据中心2022-02-20 更新70
Exploring evolutionary trajectories in ovarian cancer patients by longitudinal analysis of ctDNA
ABSTRACTBackground: We analysed, whether temporal heterogeneity of ctDNA mirrors evolutionary patterns in ovarian cancer.Methods: Targeted sequencing of 275 cancer-associated genes was performed in a
NIAID Data Ecosystem10
