DDAH1 hydrolyses ADMA to DMA and L-Cit

N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1) plays a role in the regulation of nitric oxide generation by catalyzing the hydrolysis an endogenous inhibitor of nitric oxide synthase (NOS), N(omega),N(omega)-dimethyl-L-arginine (ADMA) to dimethylamine (DMA) and L-citrulline (L-Cit) (Forbes et al. 2008, Wang et al. 2009). DDAH2, an isoform of DDAH1 previously thought to catalyze this reaction (Cillero-Pastor et al. 2012) has recently been shown to have no detectable catalytic activity against ADMA under conditions in which DDAH1 is active (Ragavan et al. 2023).

N(G),N(G)-二甲基精氨酸二甲基氨水解酶1（DDAH1）在调节一氧化氮生成中发挥着作用，通过催化一氧化氮合酶（NOS）的内源性抑制剂N(omega),N(omega)-二甲基-L-精氨酸（ADMA）水解为二甲基胺（DMA）和L-瓜氨酸（L-Cit）的过程（Forbes等，2008年，Wang等，2009年）。先前认为DDAH1可催化此反应的DDAH2同源异构体（Cillero-Pastor等，2012年）最近研究表明，在DDAH1活性条件下，DDAH2对ADMA无检测到的催化活性（Ragavan等，2023年）。