Regions showing significant group and medication effects during the encoding phase.

fROIs are displayed in Figure 3 (left column; yellow). Brodmann areas (BA) were defined by the Talairach and Tournoux atlas. Cerebellar lobules were defined by the Schmahmann atlas [61]. Coordinates represent distance in mm from anterior commissure: x, right(+)/left (−); y, anterior (+)/posterior (−); z, superior (+)/inferior (−). B = bilateral hemispheres; L = left hemisphere; R = right hemisphere; GP = globus pallidus; SMA = supplementary motor area. 1This column summarizes areas showing significant differences between the control and PD OFF groups in the temporal dynamics of activation during the first half of the hemodynamic response (encoding period; G X T). 2This column summarizes areas showing significant differences between the ON and OFF medication conditions in the temporal dynamics of activation (Med X T).