Table 2 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties

Table 2 Bioactivities of conoidecyclics A-C isolated from the organic extract of T. conoides and their molecular descriptors.
Bioactivities a (IC; mM) 50Conoidecyclic AConoidecyclic BConoidecyclic CStandardStandardAntioxidant activities aDPPH. scavenging activity1.20d ± 0.051.35c±0.021.54a±0.021.46b ± 0.04 P1.18d ± 0.03QABTS+. scavenging1.48d ± 0.011.54c±0.021.81a±0.041.69b ± 0.05P1.28e±0.02QAnti-inflammatory activities aCOX-1 inhibition3.13 c ±0.043.19 c ±0.043.35b ± 0.060.19d ± 0.01Ib12.06 a ±0.05SCOX-2 inhibition1.75 c±0.041.93b ± 0.021.99b ± 0.030.43d ± 0.02Ib16.56 a±0.05SSelectivity index b1.79 a±0.031.65b ± 0.041.68b ± 0.020.44d±0.03Ib0.73 c±0.02S5-LOX inhibition4.24 e±0.064.88 c±0.045.07b ± 0.094.51d ± 0.11Ib10.93 a±0.12SAnti-hypertensive activity aACE-I inhibition1.23c±0.021.89b ± 0.042.23a±0.020.53d ± 0.02CP–Anti-diabetic activity aPTP-1B inhibition1.39 c ±0.032.33b ± 0.023.13 a ±0.041.13d ± 0.06SV–Molecular descriptors cConoidecyclic AConoidecyclic BConoidecyclic Cα -tocopherol (BHT)Ibuprofen (Captopril)ElectronictPSA96.22122.52122.5229.46 (20.23)37.30 (57.61)PI (× 10 24 cm3)51615553.54 (27.64)23.96 (21.00)StericMR (cm3/mol)129.78154.66140.80135.6 (69.73)60.44 (54.85)MV(cm3)447.4534.9522.0462.70 (237.50)200.10 (170.7)P (cm3)1092.71316.51198.41123.00 (556.00)499.30 (463.4)HydrophobicLog POW3.133.832.619.98 (5.74)3.75 (0.24)
Different superscripts (P–V) indicate the standards used for different activities; P- α -Tocopherol; Q-Butylated hydroxy toluene; Ib-Ibuprofen; S-Sodium salicylate; CP- Captopril; SV- Sodium metavandate.
a Bioactivities were expressed as IC values (mM). Samples were analyzed in triplicate (n = 3) and expressed as mean ± standard deviation. Means followed by the 50 different superscripts (a-e) within the same row indicated significant differences (P <0.05).
b Selectivity index has been calculated as the ratio of anti COX-1(IC) to that of anti COX-2(IC).
50 50 c Structure-activity relationship analysis was carried out by using different molecular descriptors of the purified compounds as described in the text. tPSA, topological polar surface area; MV, molar volume; P, parachor; MR, molar refractivity; Log POW, logarithmic scale of the octanol-water partition coefficient; PI, polarizability.