The reasons why centromeric DNA is often A+T rich are not understood. We have used chromosome engineering to replace native centromeric DNA with different test sequences at native centromeres in two d
The centromere is a unique part of the chromosome combining a conserved function with an extreme variability in its DNA sequence. Most of our knowledge about the functional centromere organization is
The human chromosome 8 neodicentric cell line MS4221, which harbors a functional neocentromere at 8q21.2, was sequenced via long-read sequencing to resolve the VNTR at 8q21.2 and map the location of t
Centromeres, the sites of spindle attachment during mitosis and meiosis, are located in specific positions in the human genome, normally coincident with diverse subsets of alpha satellite DNA. While t
