Cleaned dataset for PubChem AID 1159555: qHTS assay of retinoic acid receptor (RAR) antagonists

This dataset is derived from PubChem BioAssay AID 1159555, titled "qHTS assay to identify small molecule antagonists of the retinoic acid receptor (RAR) signaling pathway". The original assay is part of the Tox21 program and evaluates inhibition of retinoic acid receptor (RAR) signaling using a luciferase reporter gene assay regulated by retinoic acid response elements (RARE) in a cell-based system. Original dataset statistics: - Tested compounds: 7,671 - Active (antagonists): 602 - Inactive: 5,114 Data preprocessing: - Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations. Final cleaned dataset: - Total compounds: 4,926 - Positive (antagonists): 503 - Negative (inactive): 4,423