Gene expression data of APC-mutated colorectal cancer patient-derived cells treated with tankyrase inhibitors

Tankyrase, a poly(ADP-ribose) polymerase family member, regulates multiple cellular processes. Tankyrase inhibitors efficiently suppress APC-mutated colorectal cancer (CRC) cell proliferation. To examine the mechanism of anti-proliferative effect of tankyrase inhibitors (G007LK and RK582), we analyzed gene expression profiles of patient-derived APC-mutated CRC cells (JC21 and JC475) left untreated or treated with 0.3 µM G007LK or RK582 for 24 h by cDNA microarray analysis. The patient-derived CRC cells, JC21 and JC475, were left untreated (DMSO) or treated with 0.3 µM G007LK or RK582 for 24 h. After the treatment, cells were collected and then gene expression data were obtained.