CoMtb alters the immune landscape following Mtb infection [B6 scSCRNAseq]

To characterize the influence of CoMtb on immune responses during infection, we performed single-cell RNA sequencing (scRNAseq) and flow cytometry analysis of lungs from Mtb-infected C57Bl/6 mice with and without CoMtb immediately pre-infection and at 10, 17 and 34 days after conventional dose (50-100 CFU) Mtb infection. We found that CoMtb induces rapid recruitment and activation of T cells, macrophage, and diminished late neutrophil responses. Single-cell RNA sequencing (scRNAseq) and flow cytometry analysis of lungs from Mtb-infected B6 mice with and without CoMtb immediately pre-infection and at 10. 17 and 34 days after CD infection. Variables tested including comparing timepoints to each other. and CoMtb vs non-CoMtb