Identification of the RB loss-induced transcriptome in prostate cancer [RNA]

The retinoblastoma protein (RB) is preferentially lost in the progression to castrate resistant prostate cancer (CRPC). However, the alterations associated with such loss have been scantly described. The current study aims to provide molecular mechanisms underlying Rb loss-driven CRPC phenotypes Overall design: Transcriptional alterations upon RB loss were assessed in hormone deficient conditions through RNA-Seq of shCON and shRB LNCaP prostate cancer cells