Activation and repression by oncogenic Myc shapes tumour-specific gene expression profiles

ChEBI2014-07-10 更新2026-07-21 收录

肿瘤基因调控

MYC功能研究

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Activation and repression by oncogenic Myc shapes tumour-specific gene expression profiles

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2014-07-10

The HES1 effects on TCL cells

肿瘤基因调控

淋巴结病理

This study investigated the effects of HES1 depletion on TCL cells with RNA expression profile of two ALK+ TCL cells by Highthrough sequencing RNAseq on SUDHL-1 and SUP-M2 cells with wildtype and HES1

NIAID Data Ecosystem60

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The mechanistic links between transcription factors and the epigenetic landscape, which coordinate the deregulation of gene networks during cell transformation are largely unknown. We used an isogenic

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肿瘤基因调控

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To investigate downstream pathways affected by Filip1l-knockdown, mTc11 (mouse lung cancer cell line) clones were generated by lentiviral shRNA of either scrambled control or Filip1l. We then performe

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Sulfopin, a covalent inhibitor of Pin1, blocks Myc-driven tumors in vivo. Sulfopin, a covalent inhibitor of Pin1, blocks Myc-driven tumors in vivo

靶向药物开发

MYC功能研究

The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an elusive drug target. Her

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Table_1_Downregulation of ZNF280A inhibits proliferation and tumorigenicity of colorectal cancer cells by promoting the ubiquitination and degradation of RPS14.docx

结直肠癌分子机制

肿瘤基因调控

Colorectal cancer (CRC), one of the cancers with highest mortality, involves complicated molecular mechanisms leading to the onset of malignant phenotypes. ZNF280A, a member of the zinc-finger protein

NIAID Data Ecosystem30

Activation and repression by oncogenic Myc shapes tumour-specific gene expression profiles

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