Increased susceptibility of WHIM mice to Papillomavirus-induced disease is dependent upon immune cell dysfunction

Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome is a rare primary immunodeficiency disease in humans caused by a gain of function in CXCR4, mostly due to inherited heterozygous mutations in CXCR4. One major clinical symptom of WHIM patients is their high susceptibility to human papillomavirus (HPV) induced disease, such as warts. Persistent high risk HPV infections cause 5% of all human cancers, including cervical, anogenital, head and neck and some skin cancers. WHIM mice bearing the same mutation identified in WHIM patients were created to study the underlying causes for the symptoms manifest in patients suffering from the WHIM syndrome. Using murine papillomavirus (MmuPV1) as an infection model in mice for HPV-induced disease, we demonstrate that WHIM mice are more susceptible to MmuPV1-induced warts (papillomas) compared to wild type mice. Namely, the incidence of papillomas is higher in WHIM mice compared to wild type mice when mice are exposed to low do..., , , # Data from: Increased susceptibility of WHIM mice to Papillomavirus-induced disease is dependent upon immune cell dysfunction

[https://doi.org/10.5061/dryad.pk0p2ngxn](https://doi.org/10.5061/dryad.pk0p2ngxn)

This data set contains all raw data points (in different formats) used to construct the points in figures in the manuscript. Different software/programs may be used for statistical and figure purposes. Details about softwares/programs used for each figure/subfigure are described below in Code/Software section.

## Description of the data and file structure

Figure 1A: Data in Contingency table format (shown as frequency), groups (genotype and infected virus dose), outcomes (papilloma or none). File format Prism Graphpad.

Figure 1B: Data in Column format, groups (genotype), values (papilloma size). File format Prism Graphpad.

Figure 1D: Data in Contingency table format (shown as fraction of total), groups (genotype), outcome (Normal, Mild Dysplasia, Moderate Dysplasia, Severe ...