1-(2,4,6-Triisopropylphenyl)ethylamine: A New Chiral Auxiliary for the Asymmetric Synthesis of γ-Amino Acid Derivatives
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https://figshare.com/articles/dataset/1_2_4_6_Triisopropylphenyl_ethylamine_A_New_Chiral_Auxiliary_for_the_Asymmetric_Synthesis_of_Amino_Acid_Derivatives/3032170
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资源简介：
The title compound has proven to be an excellent chiral auxiliary for nitrones in SmI2-mediated reductive
coupling with α,β-unsaturated esters. A variety of such nitrones, prepared from aldehydes and enantiopure
N-hydroxy-1-(2,4,6-triisopropylphenyl)ethylamine, afforded γ-N-hydroxyamino esters in high yields and
diastereomeric purity. These adducts, readily available as either enantiomer, could be transformed into
γ-N-acetoxyamino esters, N-Boc-γ-amino esters, and γ-lactams.
创建时间：
2016-02-29
