Severity of lung function impairment drives transcriptional phenotypes of COPD and relates to immune and metabolic processes. Severity of lung function impairment drives transcriptional phenotypes of COPD and relates to immune and metabolic processes

Gene expression profiles were generated from induced sputum samples in COPD and healthy controls. The study identified transcriptional phenotypes of COPD. Overall design: This study used unsupervised hierarchical clustering of induced sputum gene expression profiles of 72 stable COPD patients and 15 healthy controls to identify distinct and clinically relevant transcriptional COPD phenotypes.