MobiDB

MobiDB is a database of intrinsically disordered regions (IDRs) and related features from various sources and prediction tools. Different levels of reliability and different features are reported as different and independent annotations. The database features three levels of annotation: manually curated, indirect and predicted. MobiDB annotates the binding modes of disordered proteins, whether they undergo disorder-to-order transitions or remain disordered in the bound state. In addition, disordered regions undergoing liquid-liquid phase separation or post-translational modifications are defined.MobiDB是一个收录固有无序区域（intrinsically disordered regions，IDRs）及相关特征的数据库，其数据来源涵盖各类公开数据源与预测工具。该数据库将不同可靠性层级与特征项作为独立注释条目进行呈现，共包含三类注释层级：手动注释（manually curated）、间接注释与预测注释。MobiDB可注释无序蛋白的结合模式，包括其是否会发生无序-有序构象转变，或是在结合状态下仍维持无序状态。此外，该数据库还定义了参与液-液相分离或发生翻译后修饰的无序区域。

搜集汇总

背景与挑战

背景概述

MobiDB是一个专注于蛋白质内在无序区域（IDRs）和移动注释的数据库，提供从手动注释到预测的多级别可靠性特征。该数据库包含超过2.45亿个条目，涵盖结合模式、相分离驱动和翻译后修饰等多种功能注释，支持多种生物体分析。