Effectiveness of acute L-arginine supplementation on physical performance in strength training: a systematic review and meta-analysis

The oral administration of L-arginine has been related to improved physical performance due to a likely reduction in muscle fatigue, resulting from the vasodilator effect of nitric oxide on skeletal muscle. However, there is no precise and quantitative analysis of the information in the literature. Objective: The main objective was to assess the effectiveness of L-arginine supplementation on physical performance in strength training with a systematic review and meta-analysis. Methods: Systematic review and meta-analysis, the PRISMA® (Preferred Reporting Items for Systematic Reviews and Meta-Analysis), PICOS statement and methodology guidelines, the quality of evidence by Classification of Assessment, Development and Assessment Recommendations (GRADE), Multiple Systematic Review Tool Assessment (AMSTAR2), and to assess the risk of bias of randomized clinical trials, the RoB 2.0 tool (Risk of Bias - Cochrane risk of bias tool revised for randomized trials). The inclusion process establish...