Univariable and multivariable analyses of the association between specific predictors and mutations in dhfr, dhps, and dhfr/dhps combined.

NOTE. CI, confidence interval; OR, odds ratio; SP, sulfadoxine-pyrimethamine; CTX, cotrimoxazole.adhfr triple mutant was analyzed by grouping wild type, single and double genotypes as the reference category.bdhps mutations were analyzed as 3 genotype categories: (1) wild type, (2) single, and (3) double.cdhfr and dhps combined mutations were analyzed as 3 genotype categories: (1) wild type, single, double, and triple, (2) quadruple, and (3) quintuple.dDerived from multivariable logistic regression, controlling for age, sex, parasite density, hemoglobin level, and GIS distance to shore.eDerived from multivariable cumulative logistic regression, which models the probability of more mutations compared to fewer, controlling for age, sex, parasite density, hemoglobin level, and GIS distance to shore.fModel containing SP and/or CTX use as a predictor.gModel containing SP use only as a predictor.hYear 5 survey versus baseline.*Statistically significant, p