Allele-specific methylation effects in smoking-related genomic regions

The project aimed to explore the impact of allele-specific methylation on performance of the DNA methylation-based predictive models. The data are sequencing a set of smoking-related targets from corresponding EWAS. The data were obtained with DNA samples from whole blood of smokers and non-smokers of MHRC schizophrenia patients and healthy controls. Modified ("panhandle") version of Yang et al 2015 SMRT-BS method (long bisulfite PCR with Pacbio sequencing) was used.