Predicted impact of mutations (structure-based).
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For mutations in CaMK domain (R28L and Y268H), the structure 3c0i.pdb was used. For mutations in the SH3-GuK domain (Y728C and W919R), the homology model based on 1 kgd.pdb and 1 kjw.pdb was used. Positive ΔΔG values suggest that the indicated mutation destabilizes CASK’s overall fold.
创建时间：
2015-12-02
