TAS-120 covalent structure with FGFR2 molecular brake mutant

TAS-120 covalent structure with FGFR2 molecular brake mutant Descriptor: 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one, Fibroblast growth factor receptor 2, SULFATE ION Authors: Hoffman, I.D, Nelson, K.J, Bensen, D.C, Bailey, J.B. Deposit date: 2024-02-22 Release date: 2025-01-01 Last modified: 2025-04-09 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A model for decoding resistance in precision oncology: acquired resistance to FGFR inhibitors in cholangiocarcinoma. Ann Oncol, 36, 2025