Huntingtin Degradome Foundation Atlas

Huntingtin Degradome Foundation AtlasThis open-access dataset introduces Version 1 of the Huntingtin Degradome Foundation Atlas, a curated proteolytic peptide resource designed to accelerate translational research in neurodegeneration.
The atlas integrates proteolytic fragments from Huntingtin wild-type (WT), Q75, and Q103 isoforms, capturing the impact of polyglutamine repeat expansions that drive Huntington disease (HD) pathology. By mapping and annotating these breakdown products, the dataset provides a framework for tracking disease-relevant proteolysis.
These data are particularly relevant for clinical researchers engaged in antisense oligonucleotide (ASO) trials or biomarker-guided therapeutic development. The atlas allows cross-referencing of peptide signatures with treatment response, supporting biomarker discovery, stratification, and outcome validation in HD studies.
Each peptide entry is annotated with detailed chemical features of its proteolytic origin. The dataset is delivered as a comma-delimited ASCII (.csv) file for integration into bioinformatics and statistical pipelines. For efficient distribution, it is provided in compressed format, which can be extracted using:
tar -xvJf Huntingtin_WT_Degradome_Foundation_Atlas_v1.tar.gz
Reproducibility
All datasets can be regenerated using open-source tools (Python, BLAST, SAS). Fully documented Python scripts are included in the repository to ensure transparency and adaptability to local environments, following the methodology described in [1].

Reference
[1] Petzold A. Proteolysis-Based Biomarker Repertoire of the Neurofilament Proteome. J Neurochem. 2025 Mar;169(3):e70023. doi: 10.1111/jnc.70023. PMID: 40066701; PMCID: PMC11894590.