Pd(II)-Catalyzed Intermolecular Direct C–H Bond Iodination: An Efficient Approach toward the Synthesis of Axially Chiral Compounds via Kinetic Resolution

An efficient protocol to synthesize axially chiral compounds via kinetic resolution by Pd­(II)-catalyzed direct C–H iodination was realized (up to s = 27). The iodide product could be easily transformed to aryl-substituted pyridine N-oxides via the Suzuki–Miyaura coupling, which proved to be a suitable catalyst in asymmetric allylation of benzaldehyde with allyl­trichloro­silane.