Chip-chip from MDA-MB-231 cells with SMYD2 and EZH2. Chip-chip from MDA-MB-231 cells with SMYD2 and EZH2

The histone methyl transferase EZH2 and SMYD2 are master epigenetic regulators involved in histone methylation and gene transcription repression. Here, we report that SMYD2 and EZH2 may act as a complex in transcriptional regulation and are involved in the progression of breast cancer. ChIP-on-chip assays were performed to find unique promoters co-targeted by EZH2 and SMYD2 in MDA-MB-231 cells. Overall design: comparison of SMYD2 and EZH2 target genes in MDA-MB-231 cell line.